1. Oct 29, 2020

OCT measurements are potential biomarkers for Parkinson’s disease

There are strong associations between optical coherence tomography (OCT) measurements and Parkinson’s disease, according to a study.

Researchers conducted a search of PubMed, Embase, Web of Science, and Cochrane Library databases for observational studies which compared the OCT measurements between patients with Parkinson's disease (PD) and healthy controls. Thirty-six observational studies, including 1712 patients with Parkinson’s disease (2548 eyes) and 1778 healthy controls (2646 eyes) were identified.

Patients with Parkinson’s disease were found to have a significant reduction in mean peripapillary retinal nerve fiber layer (pRNFL) thickness, all quadrants at pRNFL, macular fovea, all outer sectors thickness at macula, macular volume, and macular ganglion cell complex (mGCC) thickness.


Zhou WC, Tao JX, Li J. Optical coherence tomography measurements as potential imaging biomarkers for Parkinson's disease: A systematic review and metaanalysis. E J Neuro. 2020; https://doi.org/10.1111/ene.14613.